Definition: Intermetatarsal neuromas result from an irritative process of the common digital nerve most frequently supplying the third and fourth toes. It is not cancerous and it is not a true tumor but a reactive and inflammatory process resulting in an enlarged nerve. Typically symptoms are aggravated by walking and relieved by removing shoes. Patients often relate stopping to pull off their shoes and rubbing their foot as common findings. There are conservative therapies, however; treatment usually becomes a surgical problem. Conservative therapies generally consist of wider shoes, injections, and padding. Surgical therapy involves removing the neuroma and is an outpatient procedure, usually accompanied by a walking shoe for several weeks.